Human insulin receptor monoclonal antibody IR 18-34
Technology No.
Hybridoma cell line producing IR 18-34 antibodies raised against the extracellular domain of the human insulin receptor which are mouse monoclonal antibodies of the IgG2a isotype. Has been shown to cross react very weakly with bovine, porcine and ovine but not rabbit, rat or mouse insulin receptors. It has been shown to cause up to 50% inhibition of insulin binding and has been used in immunohistochemistry, immunoprecipitation and blocking assays.
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swap_vertical_circlemode_editAuthors (1)Herman Waldmann
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swap_vertical_circlelibrary_booksReferences (5)
- N P J Brindle; J M Tavare; M Dickens; J Whittaker; K Siddle (June 15 1990), Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA, The Biochemical Journal, 268(3), 615-620
- R M O'Brien, M A Soos, K Siddle (20 December 1987), Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules, The EMBO Journal, 6(13), 4003-4010
- R Taylor, M A Soos, A Wells, M Argyraki, K Siddle (15 February 1987), Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor, The Biochemical Journal, 242(1), 123-129
- M A Soos, K Siddle, M D Baron, J M Heward, J P Luzio, J Bellatin, E S Lennox , Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor, The Bio
- M A Soos, K Siddle, M D Baron, J M Heward, J P Luzio, J Bellatin, E S Lennox (1 April 1986), Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor, The Biochemical Journal, 235(1), 199-208
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swap_vertical_circlecloud_downloadSupporting documents (1)Product brochureHuman insulin receptor monoclonal antibody IR 18-34.pdf
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